While safe at therapeutic doses, chronic use or overdose can result in a rare but clinically important complication like high anion gap metabolic acidosis (HAGMA)
doi: 10.1002/hep.29238 201 FangYJiLZhuCXiaoYZhangJLuJet al
These studies will help determine optimal dosing, identify which patient populations benefit most, and establish the long-term safety profile for this dual-purpose application
Why diet matters on GLP-1s GLP-1 medications and dual incretin medications (for example semaglutide and tirzepatide) can increase fullness and slow digestion, which can reduce cravings and portion sizes, but may also trigger GI side effects like nausea, vomiting, heartburn, bloating, diarrhea, and constipation, especially during dose increases
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